CML Drug Resist

" Chronic my -- leukemia or CML is a cancer of the blood with a bone marrow produces large numbers of mildly or white blood cells. It's a slow growing or chronic cancer but it may take years to progress. Early symptoms are few and a diagnosis of CML. Often catches patience by surprise."

" I had my own business and I took one of those very fancy integrity good central Methodist hospital. And perfect. Every category except warm and out of my white blood flow. They were. 19500. He had what he called chronic phase CNN so he wasn't very unless they just -- these. Doctor Kate whom -- it. But patients have 200000. On -- cannot afford to call. -- I was calling her."

" Doctor contortions started Willard on what was the best treatment at the time. Two medications. Interferon and -- city."

" DNA results are generally modest and this patent is associated -- That's significant side effects it's mean drug wants to make it did good -- law."

" For two years Willard tough it out through daily injections flu like side effects fevers extreme fatigue. And a sixty pound weight loss. I wanna open emergency we're on here. We're going to reform got a -- What's more his CML had become resistant to the interferon and heresy. But by 1999. And researchers at MD Anderson and elsewhere were testing a new treatment for CNO. A drug that would come to be called police back."

" So I think even though. Because baby it's pretty disappointed that. He wasn't responding well anymore to do -- on -- he went looking forward to putting him on this medication and seeing how he doesn't. Doctor -- cars and can't tell me he says I -- we got something in common. Hell we'll help you mean where are the best thing he'd -- back and we had some inclination that it was an hour quiet."

" And not so well -- it makes him the sixteenth. And I've been told that I was reported that patient put on here. And then. In March or April. When I got the results of -- Ballmer. I was. Pretty close to our -- Felt a lot better."

" Within three months from start to get treatment. Yet achieved that compete not the logic commission and that lasted for about two years. So he had been very effective growth -- disease."

" The first two years on -- back Willard achieved a significant response the leukemia was affecting fewer than one in 200 of his white blood cells. But then it came back. The number of Philadelphia positive sells a marker for senior -- had increased to 50%. Doctor can -- and knew that one of every ten patients with this early stage CML would become resistant to -- He thought that doubling the dose likely to act would give Willard a second chance at remission."

" at that point in time might talk to him about it I talked to him about. Our experience where many patients who had become resistant to India had been those of -- back. He responded to a higher village when we started that when and they just look at my record they said hey this just happened to a lot of other. Patient and we have doubled their dosage and they've done well. -- you didn't have a choice. Arsenal kind well we got him back. What is referred to as far from effective and I think response. Meaning that you can identify that the fans are now under 35%. In fact. In this case they -- 15%. And that's important because in the -- apart from. Article please -- does -- think response has been associated with the bat that sort of -- my side effects increased a little bit more swelling and they go and and they aren't -- of the Iraq and Somalia side effects. When we Bubba the ghostly -- that he did not experienced much more on the side effects. As. Doctor can charge and home loan bank he should CML are very hard to get rid. So we may have a profile. That you know -- kilometers -- heaven and don't feel like a denial. No you don't you just say hey Alan Garcia now. Dear life of patients with chronic -- the king has changed dramatically since you back became available. Because the -- if they can buy -- has very few side effects and at school because the disease very effective. So even if he cannot sometimes talk about the war killer because we can not. They're most state and in the nation of the disease and all of the patients. We can't talk sometimes about what's going to function on here meaning that. Even though the disease is there it's not going to affect. You've heard the quantity of life or just sort of -- of the patients now remember --"

" I have very. Grin that. You should know the first guy I've ever known. But they've developed a drug. That would help you -- belittle it. But children."