Lipodystrophy in HIV Disease

" dystrophy is a condition that many people with HIV experience. In which there are unusual changes in the distribution of body fat."

" Many of these patients who moves back in the face so didn't shoot they have a sunken -- appearance sometimes can also get lose fatter soft tissue and temples that people can medicine particularly on the links for most -- arms. We stops me. That's you know athletic appearance because -- throughout the muscles become more instrumental amongst the early. Maybe get some patients in addition."

" You won't have. Picking up and an enlargement. Of the -- back and neck so who -- pat the hump as a matter of fact it's called buffalo hump."

" Intended to have allowed me in large -- it almost looks and some patients like they go bowling ball and they're going to pregnant."

" The psychological impact of these body changes can be enormous."

" In some individuals would also be challenges often say people. Generally becoming depressed becoming socially withdrawn."

" People feel like they can't go out in public without someone looking at them that's familiar with HIV disease and treatment say aha there's someone with HIV."

" In addition to a usual weight gain and loss. Patients with -- dystrophy often have elevated blood levels of cholesterol and triglycerides. And those changes can be life threat."

" The medical condition associate who -- catastrophe. Is that of an increased risk of accelerated. Atherosclerosis hardening of the arteries in increasing income and risk of having heart attack and stroke."

" People with like -- dystrophy can also developed insulin resistance. And although it is rare patients can experience a dangerous buildup in the blood on metabolic byproduct called black --"

" So the consequences. Of the losing a lot of fast. In the short term might be largely cosmetic swiftly student constant psychological. In the long term play and I also have repercussions for other rooms -- of the don't affect heart disease potentially pancreatitis. I'm gonna -- with a similar conclusions."

" The condition now known as -- dystrophy emerged only recently as effective HIV therapies became available in the late 1990s. Doctors started seeing the high blood lipid levels and the changes in body fat in patients who otherwise were quite well."

" The cost of -- dystrophy is still -- To be very brief and very blunt the other certain aspects of the syndrome that are really related to the trucks that."

" It's pretty ace inhibitors one of the important categories of HIV medication. Have been linked to some aspects of like -- dystrophy. Especially the elevated levels of cholesterol and triglycerides. Other HIV medications have also been associated with the condition."

" Other. Associations between anti virus and what we're dystrophy arm between the new cool site analogue and loss of fat. And there are a number of drugs that seem to be blamed -- more than others for loss of fat but when you really look at the data. The whole class of drugs may actually cause some toxicity so we're really not sure what's causing all this -- put it turns out it may or may not be related to medications. The medications may accelerate an underlying process."

" To look for other possible risk factors a large study the HIV outpatient study or hops surveyed thousands of patients."

" They found that people were over age forty. People who have been on anti viral therapies. For a longer period of time people who have been HIV positive for more than 7 NEWS or have had an aids diagnosis for more than two years. People who have very little T cell count at some point in time these are known drug risk factors for developing multiple dystrophy."

" Other risk factors identified included Caucasian ethnicity. Family history of diabetes. Low body mass high viral load. And a quick increase in T cells after starting medication. Despite all the research doctors still have not been able to define exactly what causes the condition."

" Let the district who probably is not one single condition it's probably a bunch of overlapping conditions. And that's why it's been so difficult to define."

" Some patients with like a district -- can be helped by changing anti retroviral regiments. Cholesterol and triglycerides levels can be lowered through exercise. Changes in diet and with medication. Fat loss is proving harder to treat except perhaps with plastic surgery. Concerns over the cosmetic aspects of like -- dystrophy coupled with misunderstanding about its causes are interfering with treatment decisions."

" I do have patients who refers to started anti viral therapy because you're afraid that communications are the cause of the religions are going to cause like a dystrophy."

" Other patients are demanding breaks in their therapy a course that's still experimental. And controversial. But doctors say the most dangerous symptoms of like -- dystrophy are very treatable. And that patients must realize there's no reason to avoid HIV medications."

" There's so many different factors that come into play in the development of weapons dystrophy that I think the take home message for the patient is. Don't be afraid of your medications because it's not just the medications and I think a person needs to weigh the risks and benefits of anti viral therapy begins they need potential risks of what -- dystrophy and I would argue that in almost every case. The benefits of anti viral therapy win now."