Radioimmunotherapy: Safety Measures During Therapy

" One of the newest developments in the treatment of non hodgkin's lymphoma or any Al is radio immunotherapy. At a guild club gathering in Chicago."

" This treatment was the main topic of discussion by going to injection and amount and a -- I'm gonna make antibodies. In their antibody. 1990 finally I don't. Non Christians and green and I was -- seeing things anytime there's any opportunity to go anywhere to get information. To these treatments. -- on the right we don't try to go radio immunotherapy."

" Uses drugs called monoclonal antibody. Which are similar to enter body's immune system makes to fight infection. The -- to bodies have a radio active component attack -- which attacks a protein on the surface of the cell and destroy it felt. Currently radio immunotherapy. Is primarily being used in the fight against any out."

" The reason radio and there -- thinkers have been targeted right now and hallmark. As we announced the right target Edie twining antigen is limited to be -- I'm sorry I'm lymphoma cells are very sensitive to radiation therapy. I am so we've always wondered -- be great if we could just reunion a lot of these different sites. But assuming normal tissue structures if you radiate commitment of providing that the tax and he becomes a this is a very attractive radiating a whole body. Without having to expose and an amount of normal to --"

" Radio immunotherapy. Differs from traditional radiation therapy in several -- traditional radiation. Target -- tumor -- but it leaves probably untreated. In -- cells that might be voting in other area and our traditional radio in his very active players creating a localized tumor but radio therapy offers an opportunity to deliver radiation. Multiple sites. In a targeted fashion and we hope they dose."

" Most radio therapy. And traditional way of external being. You round and in front of the Linear accelerator and obviously the first thing -- has happened is the regulation has to go through you and another normal tensions before it hit. The ground target of interest by getting -- therapy to radiate and his crew are right there petitioners have interest. -- antibody that the radioactivity. And tell the difference between. An external beam often is Monday through Friday. For many weeks in reading and you know therapy and one treatment of one week on treatment the next week. And around with an image obtained. To make rather than the radioactivity distributing itself properly and and so."

" The current treatment regiment uses a drug called Evelyn Evelyn has two components a monoclonal antibody with radioactive tritium attached -- it. But before a patient is given Evelyn face first -- feed -- non radioactive counterpart Rick talk."

" On the per day a dose of playing their talks and Colbert -- is given first. It immediately afterwards. A dose of radioactive about it is given we do body scans and -- scene where the radioactivity is going one week later. Patients come back. All outpatient. And they get another dose of cold Rick -- and then immediately afterwards they get it done. It treat them like an idea and injections then -- go home. And then what we have asked people there has come back and give blood counts once a week. Our experience and within about four to six weeks the white blood count drops and the play of account dropped. And those levels have been dropped -- are potentially. Serious and that they can result in infections. But fortunately what we've seen so far is that there are very few infections that occur. Following treatment for example and even though the white blood count and is --"

" A common question that arises about this treatment who are the best candidate the -- and screw our candidate Evelyn. Therapy to patients who have recurrent or relapse or tractor in -- transformed. -- be done -- in Oklahoma who have not had a lot of prior external beam radiation. Who have not had -- transplant. Did not have when and 25% bone marrow compartment and has otherwise good organ function. -- side effects other than their aviation side effects are mostly related to -- holding an abiding that we used in the attack and that there. -- fever chills a little keys. And it is very non specific. Very well managed and not --"

" one -- the most common questions that we get from pain and after the that the therapy will -- And he -- being a risk. To family members. And we can -- answers the risk is very small family members can can can -- fairly safe. After exposure to their loved ones after they've been treated for example and we regard the precautions -- a hole in. He -- simple universal precautions basically disposing of ways you can use the -- the condoms. Four. A sexual relations for about a week after after treatment. Hand washing soccer ball movement. Are you in the bathroom the overall response rate was about like 7% and hours in response is not forty or 50% and now like sixty or 70%."

" Radio immune therapy is proving to be a promising new area of treatment for non hodgkin's lymphoma patient. That possibly could be used to fight other forms of cancer in --"

" Sure I think the next chapters and had a combine it -- whether it's human therapies like chat block other antibodies that are under development. Right now most of the data with drugs like Evelyn and -- and I and molecular. And low grade I don't that there are a lot of patience I'm Margaret and and home Islam and to our own home and want to know hey how does -- work for me. And I think that the questions and and I'm going to be."